Will these computer parts work together?

The parts you picked are certainly in the upper level of computer technology. Much of your system will work flawlessly although the hard drives are SATA III 2.5's and are more typically used for laptops. Desktop computers take 3.5" HD's The Pony's you want to pair with the X58 may also try your patience as they are pretty hard to pair with just any MB. I have the MB you selected with the i7 Extreme and I can tell you this right off the bat! BETTER COOL IT WITH WATER! I tried just about everything and did not see the full potential of the processor until I hooked it to my Thermaltake LCS. It is sweet. I really like your idea here - the items will certainly create a faster than fast DT. You really need to ensure you pair the right OS with those Pony's... like I said, they are picky little turkeys and are more typically used for film-making, not gaming. But they should launch any game on the market with flawless perfection. Good picks.